Targeting the Underbelly of Methamphetamine Neurotoxicity: Molecular Insights and Therapeutic Approaches for Combatting Neurodegeneration and Inflammation

Abstract

Methamphetamine (METH) abuse continues to exact a devastating toll on individuals and society, with profound neurotoxic effects on the central nervous system (CNS). This review delves into the molecular intricacies underlying METH neurotoxicity and explores emerging therapeutic strategies aimed at mitigating neurodegeneration and inflammation associated with chronic drug exposure. Through a comprehensive examination of neurochemical pathways and cellular mechanisms, the underbelly of METH-induced CNS damage is unraveled, including oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation. Furthermore, promising therapeutic interventions targeting these molecular pathways, including antioxidants, anti-inflammatory agents, and neuroprotective compounds, are discussed. By elucidating the molecular landscape of METH neurotoxicity and highlighting innovative treatment approaches, this review aims to inform future research efforts and clinical interventions aimed at combating the devastating consequences of METH abuse on brain health. By bridging the gap between basic research and clinical application, novel therapeutic interventions targeting specific molecular pathways implicated in METH neurotoxicity can be developed and optimized. Additionally, early detection of CNS damage through the identification of biomarkers may enable timely interventions to prevent further deterioration and facilitate recovery. Collaborative efforts among researchers, clinicians, policymakers, and community stakeholders are essential to comprehensively address the multifaceted challenges posed by METH abuse.